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Temperature Control of chemical reactors

Certain API manufacturing steps—such as exothermic or low-temperature chemical reactions (e.g. chiral synthesis)—require low or very low temperatures to be safely and efficiently controlled. Liquid nitrogen can be used to indirectly cool the reaction medium and to maintain a low temperature so that the right chemical reactions can occur.

Air Liquide’s CRYO COOLING UNITs take control of your chemical reactions and cooling needs through precise temperature regulation. Cryogenics replace the need for CFCs and are particularly suited for very low temperatures. The high available cooling power allows you to safely control exothermic reactions. If cooling and heating cycles are required, we offer a heating module using low pressure steam as an option. With this combination, we can control a wide range of processes from temperatures as low as -140°C to +200°C with fast start-up and short cycle times. Air Liquide offers many standard turnkey solutions with refrigerant capacities of up to100 kW.




Air Liquide provides engineering support including sizing, consumption estimates, and equipment recommendations. We can perform tank inerting audits to help you maintain an inert environment. We provide gas handling safety expertise and a range of resources, including Certificates of Analysis (CoA) upon request.

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